References
1. The glaucomas. Vol I & II. Eds: Ritch R., Shields M.B., Krupin T. St.Louis: Mosby; 1996.
2. Tuulonen A, Airaksinen PJ. Initial glaucomatous optic disk and retinal nerve fiber layer abnormalities and their progression. Am.J.Ophthalmol. 1991;111:485-490.
3. Quigley HA, Addicks EM, Green WR, Maumenee AE. Optic nerve damage in human glaucoma. II. the site of injury and susceptibility to damage. Arch.Ophthalmol. 1981;99:635-649.
4. Quigley HA, Addicks EM. Regional differences in the structure of the lamina cribrosa and their relation to glaucomatous optic nerve damage. Arch.Ophthalmol.1981 Jan;99(1):137-143.
5. Radius RL, Gonzales M. Anatomy of the lamina cribrosa in human eyes. Arch.Ophthalmol. 1981;99:2159-2162.
6. Jonas JB, Fernandez MC, Sturmer J. Pattern of glaucomatous neuroretinal rim loss. Ophthalmology 1993;100:63-68.
7. Anderson DR. Optic nerve blood flow. S. M. Drance and D. R. Anderson. In Optic Nerve in Glaucoma. New York: Kluger publications; 1995. 311-331 pp.
8. Cioffi GA. Vascular anatomy of the optic nerve. L. E. Pillunat, A. Harris, D. R. Anderson and I. L. Greve. In Current Concepts on Ocular Blood Flow in Glaucoma. The Hague, The Netherlands: Kugler Publications; 1999. 45-50 pp.
9. Hayreh SS. Blood supply of the optic nerve head. A 'reality check'. L. E. Pillunat, A. Harris, D. A. Anderson and E. L. Greve. In Current Concepts on Ocular Blood Flow in Glaucoma. Hague, Netherlands: Kugler Publications; 1999.
10. Hayreh SS. Blood flow in the optic nerve head and factors that may influence it. Prog.Retin.Eye Res. 2001;20:595-624.
11. Sehi M, Flanagan JG, Zeng L, Cook RJ, Trope GE. Anterior optic nerve capillary blood flow response to diurnal variation of mean ocular perfusion pressure in early untreated primary open-angle glaucoma. Invest.Ophthalmol.Vis.Sci. 2005;46:4581-4587.
12. Grieshaber MC, Flammer J. Blood flow in glaucoma. Curr.Opin.Ophthalmol. 2005;16:79-83.
13. Bellezza AJ, Hart RT, Burgoyne CF. The optic nerve head as a biomechanical structure: Initial finite element modeling. Invest.Ophthalmol.Vis.Sci. 2000;41:2991-3000.
14. Burgoyne CF, Downs JC, Bellezza AJ, Suh JK, Hart RT. The optic nerve head as a biomechanical structure: A new paradigm for understanding the role of IOP-related stress and strain in the pathophysiology of glaucomatous optic nerve head damage. Prog.Retin.Eye Res. 2005;24:39-73.
15. Downs JC, Suh JK, Thomas KA, Bellezza AJ, Burgoyne CF, Hart RT. Viscoelastic characterization of peripapillary sclera: Material properties by quadrant in rabbit and monkey eyes. J.Biomech.Eng. 2003;125:124-131.
16. Cioffi GA, Granstam E, Alm A. Ocular circulation. P. Kaufman and A. Alm. In Adler's physiology of the eye. Elsevier; 2002. 747-784 pp.
17. Yu DY, Cringle SJ. Oxygen distribution and consumption within the retina in vascularised and avascular retinas and in animal models of retinal disease. Prog.Retin.Eye Res. 2001;20:175-208.
18. Gupta D. Pathophysiology of glaucoma. In Glaucoma Diagnosis and Management. Philadelphia: Lippincott Williams & Wilkins; 2004. 31-39 pp.
19. Cantor L, Fechtner R, Michael AJ, Simmons ST, Wilson MR, Brown SVL. Clinical evaluation; the optic nerve anatomy and pathology. M. Denny and J. Daniel. In Glaucoma Basic and Clinical Science Course. San Francisco: 2004. 39-42 pp.
20. Mackenzie PJ, Cioffi GA. Vascular anatomy of the optic nerve head. Can.J.Ophthalmol. 2008;43:308-312.
21. Buchi ER. The blood supply to the optic nerve head. H. J. Kaiser, J. Flammer and Ph Hendrickson. In Ocular Blood Flow; New Insights into the Pathogenesis of Ocular Diseases. Basel: Karger Publications; 1996. 1-8 pp.
22. Mozaffarieh M, Flammer J. Is there more to glaucoma treatment than lowering IOP? Surv.Ophthalmol. 2007;52 Suppl 2:S174-9.
23. Grieshaber MC, Mozaffarieh M, Flammer J. What is the link between vascular dysregulation and glaucoma? Surv.Ophthalmol. 2007;52:S144-54.
24. Grieshaber MC, Terhorst T, Flammer J. The pathogenesis of optic disc splinter haemorrhages: A new hypothesis. Acta Ophthalmol.Scand. 2006;84:62-68.
25. Plange N, Kaup M, Weber A, Arend KO, Remky A. Retrobulbar haemodynamics and morphometric optic disc analysis in primary open-angle glaucoma. Br.J.Ophthalmol. 2006;90:1501-1504.
26. Kaiser HJ, Schoetzau A, Stumpfig D, Flammer J. Blood-flow velocities of the extraocular vessels in patients with high-tension and normal-tension primary open-angle glaucoma. Am.J.Ophthalmol. 1997;123:320-327.
27. Michelson G, Langhans MJ, Harazny J, Dichtl A. Visual field defect and perfusion of the juxtapapillary retina and the neuroretinal rim area in primary open-angle glaucoma. Graefes Arch.Clin.Exp.Ophthalmol. 1998;236:80-85.
28. Michelson G, Langhans MJ, Groh MJ. Perfusion of the juxtapapillary retina and the neuroretinal rim area in primary open angle glaucoma. J.Glaucoma 1996;5:91-98.
29. Kornzweig AL, Eliasoph I, Feldstein M. Selective atrophy of the radial peripapillary capillaries in chronic glaucoma. Arch.Ophthalmol. 1968;80:696-702.
30. Tezel G, Kass MA, Kolker AE, Wax MB. Comparative optic disc analysis in normal pressure glaucoma, primary open-angle glaucoma, and ocular hypertension. Ophthalmology 1996;103:2105-2113.
31. Pournaras CJ, Rungger-Brandle E, Riva CE, Hardarson SH, Stefansson E. Regulation of retinal blood flow in health and disease. Prog.Retin.Eye Res. 2008;27:284-330.
32. Orgul S, Gugleta K, Flammer J. Physiology of perfusion as it relates to the optic nerve head. Surv.Ophthalmol. 1999;43 Suppl 1:S17-S26.
33. Anderson DR. Glaucoma, capillaries and pericytes. 1. Blood flow regulation. Ophthalmologica 1996;210:257-262.
34. Anderson DR, Davis EB. Glaucoma, capillaries and pericytes. 5. Preliminary evidence that carbon dioxide relaxes pericyte contractile tone. Ophthalmologica 1996;210:280-284.
35. Lombard JH. A novel mechanism for regulation of retinal blood flow by lactate: Gap junctions, hypoxia, and pericytes. Am.J.Physiol.Heart Circ.Physiol. 2006;290:H921-2.
36. Peppiatt CM, Howarth C, Mobbs P, Attwell D. Bidirectional control of CNS capillary diameter by pericytes. Nature 2006;443:700-704.
37. Harris A, Ciulla TA, Chung HS, Martin B. Regulation of retinal and optic nerve blood flow. Arch.Ophthalmol. 1998;116:1491-1495.
38. Haefliger IO, Flammer J, Beny JL, Luscher TF. Endothelium-dependent vasoactive modulation in the ophthalmic circulation. Prog.Retin.Eye Res. 2001;20:209-225.
39. Pechanova O, Simko F. The role of nitric oxide in the maintenance of vasoactive balance. Physiol.Res. 2007;56 Suppl 2:S7-S16.
40. Pournaras CJ, Riva CE, Bresson-Dumont H, De Gottrau P, Bechetoille A. Regulation of optic nerve head blood flow in normal tension glaucoma patients. Eur.J.Ophthalmol. 2004;14:226-235.
41. Gugleta K, Orgul S, Hasler P, Flammer J. Circulatory response to blood gas perturbations in vasospasm. Invest.Ophthalmol.Vis.Sci. 2005;46:3288-3294.
42. Flammer J, Mozaffarieh M. Autoregulation, a balancing act between supply and demand. Can.J.Ophthalmol. 2008;43:317-321.
43. Chauhan BC. Endothelin and its potential role in glaucoma. Can.J.Ophthalmol. 2008;43:356-360.
44. Resch H, Garhofer G, Fuchsjager-Mayrl G, Hommer A, Schmetterer L. Endothelial dysfunction in glaucoma. Acta Ophthalmol. 2009; 87(1): 4-12.
45. Dorner GT, Garhofer G, Kiss B, et al. Nitric oxide regulates retinal vascular tone in humans. Am.J.Physiol.Heart Circ.Physiol. 2003;285:H631-H636.
46. Polak K, Luksch A, Frank B, Jandrasits K, Polska E, Schmetterer L. Regulation of human retinal blood flow by endothelin-1. Exp.Eye Res. 2003;76:633-640.
47. Dallinger S, Dorner GT, Wenzel R, et al. Endothelin-1 contributes to hyperoxia-induced vasoconstriction in the human retina. Invest.Ophthalmol.Vis.Sci. 2000;41:864-869.
48. Flammer J, Mozaffarieh M. What is the present pathogenetic concept of glaucomatous optic neuropathy? Surv.Ophthalmol. 2007;52:S162-73.
49. Mozaffarieh M, Grieshaber MC, Flammer J. Oxygen and blood flow: Players in the pathogenesis of glaucoma. Mol.Vis. 2008;14:224-233.
50. Kerr J, Nelson P, O'Brien C. Pulsatile ocular blood flow in primary open-angle glaucoma and ocular hypertension. Am.J.Ophthalmol. 2003;136:1106-1113.
51. Dorner GT, Garhoefer G, Zawinka C, Kiss B, Schmetterer L. Response of retinal blood flow to CO2-breathing in humans. Eur.J.Ophthalmol. 2002;12:459-466.
52. Harris A, Anderson DR, Pillunat L, et al. Laser doppler flowmetry measurement of changes in human optic nerve head blood flow in response to blood gas perturbations. J.Glaucoma 1996;5:258-265.
53. Venkataraman ST, Hudson C, Fisher JA, et al. Retinal arteriolar and capillary vascular reactivity in response to isoxic hypercapnia. Exp.Eye Res. 2008; 87(6): 535-542.
54. Gilmore ED, Hudson C, Preiss D, Fisher J. Retinal arteriolar diameter, blood velocity, and blood flow response to an isocapnic hyperoxic provocation. Am J Physiol Heart Circ Physiol 2005;288:H2912-H2917.
55. Kiss B, Polska E, Dorner G, et al. Retinal blood flow during hyperoxia in humans revisited: Concerted results using different measurement techniques. Microvasc.Res. 2002;64:75-85.
56. Tomic L, Bjarnhall G, Maepea O, Sperber GO, Alm A. Effects of oxygen and carbon dioxide on human retinal circulation: An investigation using blue field simulation and scanning laser ophthalmoscopy. Acta Ophthalmol.Scand. 2005;83:705-710.
57. Hollo G, Lakatos P, Farkas K. Cold pressor test and plasma endothelin-1 concentration in primary open-angle and capsular glaucoma. J.Glaucoma 1998;7:105-110.
58. Nagaoka T, Mori F, Yoshida A. Retinal artery response to acute systemic blood pressure increase during cold pressor test in humans. Invest.Ophthalmol.Vis.Sci. 2002;43:1941-1945.
59. Nicolela MT, Ferrier SN, Morrison CA, et al. Effects of cold-induced vasospasm in glaucoma: The role of endothelin-1. Invest.Ophthalmol.Vis.Sci. 2003;44:2565-2572.
60. Rojanapongpun P, Drance SM. The response of blood flow velocity in the ophthalmic artery and blood flow of the finger to warm and cold stimuli in glaucomatous patients. Graefes Arch.Clin.Exp.Ophthalmol. 1993;231:375-377.
61. Prokopich CL, Flanagan JG. The association between a positive cold pressor test and vasospastic symptoms. Invest.Ophthalmol.Vis.Sci. 2003;44:E-Abstract 116.
62. Polak K, Schmetterer L, Riva CE. Influence of flicker frequency on flicker-induced changes of retinal vessel diameter. Invest.Ophthalmol.Vis.Sci. 2002;43:2721-2726.
63. Riva CE, Harino S, Shonat RD, Petrig BL. Flicker evoked increase in optic nerve head blood flow in anesthetized cats. Neurosci.Lett. 1991;128:291-296.
64. Riva CE, Salgarello T, Logean E, Colotto A, Galan EM, Falsini B. Flicker-evoked response measured at the optic disc rim is reduced in ocular hypertension and early glaucoma. Invest.Ophthalmol.Vis.Sci. 2004;45:3662-3668.
65. Horn FK, Link B, Dehne K, Lammer R, Junemann AG. Flicker provocation with LED full-field stimulation in normals and glaucoma patients. Ophthalmologe 2006;103:866-872.
66. Falsini B, Riva CE, Logean E. Flicker-evoked changes in human optic nerve blood flow: Relationship with retinal neural activity. Invest.Ophthalmol.Vis.Sci. 2002;43:2309-2316.
67. Grunwald JE, Sinclair SH, Riva CE. Autoregulation of the retinal circulation in response to decrease of intraocular pressure below normal. Invest.Ophthalmol.Vis.Sci. 1982;23:124-127.
68. Rassam SM, Patel V, Kohner EM. The effect of experimental hypertension on retinal vascular autoregulation in humans: A mechanism for the progression of diabetic retinopathy. Exp.Physiol. 1995;80:53-68.
69. Robinson F, Riva CE, Grunwald JE, Petrig BL, Sinclair SH. Retinal blood flow autoregulation in response to an acute increase in blood pressure. Invest.Ophthalmol.Vis.Sci. 1986;27:722-726.
70. Weinstein JM, Duckrow RB, Beard D, Brennan RW. Regional optic nerve blood flow and its autoregulation. Invest.Ophthalmol.Vis.Sci. 1983;24:1559-1565.
71. Weinstein JM, Funsch D, Page RB, Brennan RW. Optic nerve blood flow and its regulation. Invest.Ophthalmol.Vis.Sci. 1982;23:640-645.
72. Jeppesen P, Sanye-Hajari J, Bek T. Increased blood pressure induces a diameter response of retinal arterioles that increases with decreasing arteriolar diameter. Invest.Ophthalmol.Vis.Sci. 2007;48:328-331.
73. Reudelhuber TL. The renin-angiotensin system: Peptides and enzymes beyond angiotensin II. Curr.Opin.Nephrol.Hypertens. 2005;14:155-159.
74. Haefliger IO, Meyer P, Flammer J. Endothelium-dependent vasoactive factors. H. J. Kaiser, J. Flammer and P. Hendrickson. In Ocular blood flow. Glaucoma-meeting 1995. Basel, Karger; 1996. 51-63 pp.
75. Schmetterer L, Findl O, Strenn K, et al. Role of NO in the O2 and CO2 responsiveness of cerebral and ocular circulation in humans. Am.J.Physiol. 1997;273:R2005-R2012.
76. Riva CE, Sinclair SH, Grunwald JE. Autoregulation of retinal circulation in response to decrease of perfusion pressure. Invest.Ophthalmol.Vis.Sci. 1981;21:34-38.
77. Pillunat LE, Anderson DR, Knighton RW, Joos KM, Feuer WJ. Autoregulation of human optic nerve head circulation in response to increased intraocular pressure. Exp.Eye Res. 1997;64:737-744.
78. Schulte K, Wolf S, Arend O, Harris A, Henle C, Reim M. Retinal hemodynamics during increased intraocular pressure. Ger.J.Ophthalmol. 1996;5:1-5.
79. Riva CE, Grunwald JE, Petrig BL. Autoregulation of human retinal blood flow. an investigation with laser doppler velocimetry. Invest.Ophthalmol.Vis.Sci. 1986;27:1706-1712.
80. Lovasik JV, Kergoat H, Riva CE, Petrig BL, Geiser M. Choroidal blood flow during exercise-induced changes in the ocular perfusion pressure. Invest.Ophthalmol.Vis.Sci. 2003;44:2126-2132.
81. Flammer J, Orgul S, Costa VP, et al. The impact of ocular blood flow in glaucoma. Prog.Retin.Eye Res. 2002;21:359-393.
82. Evans DW, Harris A, Garrett M, Chung HS, Kagemann L. Glaucoma patients demonstrate faulty autoregulation of ocular blood flow during posture change. Br.J.Ophthalmol. 1999;83:809-813.
83. Flammer J, Haefliger IO, Orgul S, Resink T. Vascular dysregulation: A principal risk factor for glaucomatous damage? J.Glaucoma 1999;8:212-219.
84. Chung HS, Harris A, Evans DW, Kagemann L, Garzozi HJ, Martin B. Vascular aspects in the pathophysiology of glaucomatous optic neuropathy. Surv.Ophthalmol. 1999;43 Suppl 1:S43-S50.
85. Haefliger IO, Dettmann E, Liu R, et al. Potential role of nitric oxide and endothelin in the pathogenesis of glaucoma. Surv.Ophthalmol. 1999;43 Suppl 1:S51-S58.
86. Yorio T, Krishnamoorthy R, Prasanna G. Endothelin: Is it a contributor to glaucoma pathophysiology? J.Glaucoma 2002;11:259-270.
87. Harris A, Kagemann L, Ehrlich R, Rospigliosi C, Moore D, Siesky B. Measuring and interpreting ocular blood flow and metabolism in glaucoma. Can.J.Ophthalmol. 2008;43:328-336.
88. Weigert G, Findl O, Luksch A, et al. Effects of moderate changes in intraocular pressure on ocular hemodynamics in patients with primary open-angle glaucoma and healthy controls. Ophthalmology 2005;112:1337-1342.
89. Grunwald JE, Riva CE, Stone RA, Keates EU, Petrig BL. Retinal autoregulation in open-angle glaucoma. Ophthalmology 1984;91:1690-1694.
90. Nagel E, Vilser W, Lanzl IM. Retinal vessel reaction to short-term IOP elevation in ocular hypertensive and glaucoma patients. Eur.J.Ophthalmol. 2001;11:338-344.